(Cys(ACM)3,6) PROK2 / PK2 Isoform 2 (28-78)-Amide (Human)

(Cys(ACM)3,6) PROK2 / PK2 Isoform 2 (28-78)-Amide (Human)

(Cys(ACM)3,6) PROK2 / PK2 Isoform 2 (28-78)-Amide (Human) is a chemically synthesized peptide fragment derived from the human prokineticin-2 (PK2/PROK2) protein. The inclusion of ACM-protected cysteine residues at positions 3 and 6 provides enhanced structural stability, facilitating consistent laboratory handling and improved reproducibility in controlled research environments.

Although Prokineticins are small, secreted proteins known to bind G-protein-coupled receptors, where they play essential roles in angiogenesis, circadian rhythm regulation, immune signalling, gastrointestinal motility, and neurobiological processes. Because of this, PK2-derived peptides are frequently studied in a range of cellular and biochemical models.

Research Relevance

Although Researchers commonly select (28-78)-Amide (Human) for studies such as:

• Ligand–receptor interaction assays

• Signal transduction and pathway mapping

• Neurobiology and brain signalling studies

• Immune and inflammatory response investigations

• Endothelial and vascular biology models

• Angiogenesis-related research

• Protein function characterization

The modified cysteine residues help reduce premature disulfide bonding during preparation and storage, assisting with structural preservation and minimizing degradation risk in sensitive experimental workflows.

Quality & Specifications

Although typical specifications include:

• Form: Lyophilized powder

• Purity: Commonly ≥ 95% (HPLC)

• Sequence Region: 28-78 fragment of human PROK2 isoform 2

• Modifications: Cys(ACM) at positions 3 and 6, C-terminal amide

Each batch is produced under controlled manufacturing conditions suitable for laboratory-grade research.

Storage & Handling

Although for optimal long-term stability, it is recommended that the peptide be stored refrigerated or frozen in a dry, airtight environment. Reconstitution should be carried out using sterile laboratory-grade solvents. Avoid repeated freeze–thaw cycles. All handling should follow standard laboratory safety protocols.